Designing systems capable of producing measurable outcomes.
Designing Botanical Formulation Systems for Metabolic and Inflammatory Regulation
Precision-designed botanical systems built on compound interaction, delivery architecture, and system-level biological response.
Applied botanical systems across health, chemistry, and environmental processes.
Core Research Areas
Structured research focused on botanical formulation systems, plant-derived extraction processes, and system-level chemical interactions within biological and environmental contexts.
Analyze how botanical compounds interact to influence system-level targeted physiological outcomes ↓
Design structured botanical formulation systems that regulate inflammation, metabolism, and biological signaling ↓
Deploy mercury-free botanical extraction systems replacing toxic chemical processing in gold recovery ↓
Translating plant chemistry into real-world health and environmental outcomes.
Applied Botanical Systems in Practice
Selected applied examples demonstrating how botanical systems are structured.
Botanical Formulation Systems™ designed to influence health and environmental systems through structured botanical chemistry
A Structured Scientific Framework — Not Generic Nutrition
A systems-based approach to botanical chemistry focused on structure, delivery, and measurable outcomes.
Evidence-based - Structured - No generic recipes
Download the core framework for designing bioavailable botanical systems. • Core formulation architecture • Bioavailability principles • Ingredient selection logic
Applied Botanical Chemistry
Applied botanical chemistry transforms plant compounds into structured delivery systems with measurable physiological outcomes. These systems are engineered using: • extraction chemistry • dose structuring • bioavailability optimization to deliver functionally relevant levels of polyphenols, flavonoids, and mineral cofactors.
Bioavailable plant-based delivery systems for targeted health outcomes.
Botanical compounds alone do not drive outcomes.Their effectiveness depends on how they are structured, combined, and delivered.
High-phenolic botanicals, flavonoids, and mineral cofactors must be:
- stabilized
- correctly dosed
- delivered in bioavailable formats
to influence inflammation, metabolic function, and gut microbiome dynamics.
| This framework defines how botanical systems are engineered to produce measurable physiological outcomes |
Most botanical formulations fail due to poor structural design and ineffective delivery systems.
Formulation Systems for Targeted Outcomes
Bioavailable botanical systems are engineered to target specific physiological pathways through structured formulation design.
These systems are applied across:
- inflammation modulation
- gut microbiome balance
- metabolic resilience
- cardiovascular support
Each system integrates compound synergy, delivery format, and dose architecture to produce measurable effects.
Structured systems — not isolated ingredients — drive measurable outcomes.
Environmental Applications
Botanical chemistry extends beyond human health into environmental and industrial systems. Applications include: • mercury-free extraction systems • plant-based lixiviants • circular chemistry using agricultural byproducts • reduction of toxic environmental exposure This work demonstrates the broader applicability of botanical systems science across human and environmental domains.
“The symbiosis of artisanal ore processors and flour makers is a win-win situation to reduce environmental pollution, health threats, and mitigating an unintended consequence of harvesting the bitter cassava plant” (P. Torkaman et al., 2021).
Figure 1 - Circular Cassava–Gold Processing System.
Integration of cassava-derived lixiviant production with artisanal gold processing, enabling reduced toxic exposure, improved recovery efficiency, and shared economic value across agricultural and mining systems.
Manipueira Gold Recovery Technology, a British Columbia corporation founded in July 2021 by Bruce A. Cosgrove, BSc, MSc, (Applied Chemistry) pioneered a four-stage ESG-aligned transformative plant-based strategy designed to provide an alternative lixiviant to mercury and synthetic cyanide salts in artisanal mining systems.
The innovation applies validated solution chemistry to botanical extraction principles for safer, sustainable mineral processing to recover more gold.
In January 2026, Bruce's Technical Preprint Presentation - Four-stage ESG-aligned Transformational botanical strategy was posted on Research Gate, DOI: 10.13140/RG.2.2.10793.66400.
In January 2025, his manuscript - An Examination, Solution, and Transformative Strategy to Replace Mercury and Cyanide Salts in Artisanal Small-Scale Mining (ASM): Southern Ecuador was published in the peer reviewed Environmental Chemistry eJournal, DOI:10.2139/ssrn.5049829.
Recent research contributions in botanical chemistry, formulation systems, and sustainable extraction technologies.
Recent Research Contributions
• Why Most “Healthy Drinks” Fail: The Missing Chemistry of Botanical Systems • Botanical Formulations for Healthy Aging and Metabolic Resilience • Mercury-Free Botanical Extraction Systems